Powder lyophilized for preparing solution for
injection 50 mg and 100 mg
Trade name: Calcium folinate.
International nonproprietary name: Calcium folinate.
Pharmaceutical form: lyophilized powder for solution for intravenous and intramuscular injection.
Description: light yellow to yellow porous mass, non- uniform color. Hygroscopic.
Composition: each vial contains:
Active ingredient: calcium folinate (calculated as folinic acid) – 50 mg or 100 mg.
Excipient: methylparahydroxybenzoate.
Pharmaceutical group: Folic acid antagonist antidote, 5-fluorouracil biological action modifier, vitamin.
ATC code: V03AF03.
Indications for use:
► Intoxications caused by folic acid antagonists (methotrexate, trimethoprim, and pyrimetamine).
► Prevention of the methotrexate toxic effect when it is administered in elevated and high doses.
► Colorectal cancer (as a part of the combined therapy with fluorouracil).
► Megaloblastic anemia on the background of folic acid deficit (including one on the background of malabsorption syndrome, undernutrition, pregnancy, sprue, in infancy in case of hereditary dihydrofolate reductase deficiency).
